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Alert Number 24
June 6, 2004
Our latest article titled Flavopiridol - a Drug that May Save Lives reviews preclinical data as well as early results from clinical trials with flavopiridol, an important experimental drug. Flavopiridol is being developed by Aventis Oncology in collaboration with the National Cancer Institute. Its use is presently under investigation for a variety of solid tumors as well as hematological cancers. It offers the possibility of p53- and ATM-independent cell kill in CLL, thereby opening an important therapeutic path for patients with poor-prognosis cytogenetics. While there are issues related to the drug's toxicity, there is also hope that it can survive the early phase optimization trials to become a major drug for the treatment of CLL. Read about the potential value and possible drawbacks of this agent in our review.
Be well,
Chaya
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